Assay Detail
Binding
CHEMBL2090871
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Inhibition of Influenza A virus (A/Anhui/1/2005(H5N1)) hemagglutininin-mediated membrane fusion assessed as inhibition of H5N1 pesudovirus infection of MDCK cells using A/Anhui/1/2005(H5N1) hemagglutinin plasmid and NA plasmid from N1 subtype strain A/Thailand/Kan353/ 2004 infected in 293T cells by luciferase reporter gene assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Anhui/1/2005(H5N1)) |
| Cell Type | MDCK |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.21 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088480 | — | — | 1 | 6.66 |
| CHEMBL2088482 | — | — | 1 | 6.48 |
| CHEMBL2088468 | — | — | 1 | 6.43 |
| CHEMBL2088479 | — | — | 1 | 6.42 |
| CHEMBL2088481 | — | — | 1 | 6.25 |
| CHEMBL2088477 | — | — | 1 | 5.91 |
| CHEMBL2088470 | — | — | 1 | 5.77 |
| CHEMBL2088471 | — | — | 1 | 5.61 |
| CHEMBL2088472 | — | — | 1 | 5.61 |
| CHEMBL2088473 | — | — | 1 | 5.61 |
| CHEMBL2088469 | — | — | 1 | 5.60 |
| CHEMBL2088643 | — | — | 1 | 5.36 |
| CHEMBL2088647 | — | — | 1 | 5.29 |
| CHEMBL2088646 | — | — | 1 | 5.20 |
| CHEMBL2088649 | — | — | 1 | 5.12 |
| CHEMBL2088642 | — | — | 1 | 5.11 |
| CHEMBL2088648 | — | — | 1 | 5.04 |
| CHEMBL2088476 | — | — | 1 | 5.00 |
| CHEMBL2088474 | — | — | 1 | 4.39 |
| CHEMBL2088640 | — | — | 1 | 4.38 |
| CHEMBL2088483 | — | — | 1 | 4.31 |
| CHEMBL2088644 | — | — | 1 | 4.26 |
| CHEMBL2088484 | — | — | 1 | 4.22 |
| CHEMBL2088645 | — | — | 1 | 4.21 |
| CHEMBL2088475 | — | — | 1 | 4.18 |
| CHEMBL2088641 | — | — | 1 | 4.10 |
| CHEMBL2088478 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088480 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2088482 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2088468 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2088479 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2088481 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2088477 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL2088470 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL2088471 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL2088472 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL2088473 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL2088469 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL2088643 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL2088647 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL2088646 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL2088649 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL2088642 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2088648 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2088476 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL2088474 | — | IC50 | = | 40770.0 | nM | 4.39 |
| CHEMBL2088640 | — | IC50 | = | 41460.0 | nM | 4.38 |
| CHEMBL2088483 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL2088644 | — | IC50 | = | 54870.0 | nM | 4.26 |
| CHEMBL2088484 | — | IC50 | = | 59970.0 | nM | 4.22 |
| CHEMBL2088645 | — | IC50 | = | 61160.0 | nM | 4.21 |
| CHEMBL2088475 | — | IC50 | = | 66640.0 | nM | 4.18 |
| CHEMBL2088641 | — | IC50 | = | 79960.0 | nM | 4.10 |
| CHEMBL2088478 | — | IC50 | = | 84320.0 | nM | 4.07 |