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Assay Detail

CHEMBL2091383

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDK2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 2 (CHEMBL301)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents.
Pierce LT, Cahill MM, Winfield HJ, McCarthy FO.
Eur J Med Chem (2012) 56 : 292 -300
PubMed 22910137 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.79 5.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL341110 1 5.79
CHEMBL339948 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL341110 IC50 = 1610.0 nM 5.79
CHEMBL339948 IC50 < 60.0 nM -