Assay Detail
Functional
CHEMBL2091391
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Antiproliferative activity against human U2OS cells expressing wild type p53 after 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.75 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2089153 | — | — | 1 | 5.58 |
| CHEMBL2089151 | — | — | 1 | 5.46 |
| CHEMBL2089203 | — | — | 1 | 5.25 |
| CHEMBL2089201 | — | — | 1 | 5.14 |
| CHEMBL2089208 | — | — | 1 | 5.12 |
| CHEMBL2089204 | — | — | 1 | 4.93 |
| CHEMBL2089152 | — | — | 1 | 4.92 |
| CHEMBL2089149 | — | — | 1 | 4.92 |
| CHEMBL1909836 | — | — | 1 | 4.80 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 4.71 |
| CHEMBL2089211 | — | — | 1 | 4.56 |
| CHEMBL2089206 | — | — | 1 | 4.56 |
| CHEMBL2089209 | — | — | 1 | 4.55 |
| CHEMBL2089207 | — | — | 1 | 4.49 |
| CHEMBL2089320 | — | — | 1 | 4.47 |
| CHEMBL2089205 | — | — | 1 | 4.45 |
| CHEMBL2089210 | — | — | 1 | 4.45 |
| CHEMBL2089200 | — | — | 1 | 4.35 |
| CHEMBL2089321 | — | — | 1 | 4.17 |
| CHEMBL2089150 | — | — | 1 | 4.05 |
| CHEMBL2089202 | — | — | 1 | - |
| CHEMBL2089322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2089153 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL2089151 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2089203 | — | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL2089201 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL2089208 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL2089204 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL2089152 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2089149 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL1909836 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL2089211 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL2089206 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL2089209 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2089207 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL2089320 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL2089205 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL2089210 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL2089200 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL2089321 | — | IC50 | = | 67600.0 | nM | 4.17 |
| CHEMBL2089150 | — | IC50 | = | 88500.0 | nM | 4.05 |
| CHEMBL2089202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2089322 | — | IC50 | > | 100000.0 | nM | - |