Assay Detail
Functional
CHEMBL2091587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase in GTPgamma35S binding by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.35 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82663 | SIBENADET | 2.0 | 1 | 8.35 |
| CHEMBL1346 | DARIFENACIN | 4.0 | 1 | - |
| CHEMBL2088198 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82663 | SIBENADET | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1346 | DARIFENACIN | EC50 | > | 10000.0 | nM | - |
| CHEMBL2088198 | — | EC50 | > | 10000.0 | nM | - |