Assay Detail
Functional
CHEMBL2091664
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Antiproliferative activity against human MDA-MB-435 cells after 3 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.74 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.36 |
| CHEMBL2089141 | — | — | 1 | 6.68 |
| CHEMBL2089142 | — | — | 1 | 6.65 |
| CHEMBL2089133 | — | — | 1 | 6.33 |
| CHEMBL2089138 | — | — | 1 | 6.22 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.04 |
| CHEMBL2089140 | — | — | 1 | 5.97 |
| CHEMBL2089139 | — | — | 1 | 5.88 |
| CHEMBL2089136 | — | — | 1 | 5.88 |
| CHEMBL2089137 | — | — | 1 | 5.64 |
| CHEMBL2089135 | — | — | 1 | 5.60 |
| CHEMBL2089134 | — | — | 1 | 5.56 |
| CHEMBL2088015 | — | — | 1 | 5.43 |
| CHEMBL2089132 | — | — | 1 | 5.31 |
| CHEMBL2088017 | — | — | 1 | 5.20 |
| CHEMBL2089130 | — | — | 1 | 5.10 |
| CHEMBL2089129 | — | — | 1 | 4.98 |
| CHEMBL2089126 | — | — | 1 | 4.90 |
| CHEMBL2088016 | — | — | 1 | 4.25 |
| CHEMBL2089131 | — | — | 1 | - |
| CHEMBL2089128 | — | — | 1 | - |
| CHEMBL2089127 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL2089141 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2089142 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL2089133 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL2089138 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL2089140 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL2089139 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2089136 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL2089137 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2089135 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL2089134 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL2088015 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL2089132 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL2088017 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL2089130 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2089129 | — | IC50 | = | 10560.0 | nM | 4.98 |
| CHEMBL2089126 | — | IC50 | = | 12690.0 | nM | 4.90 |
| CHEMBL2088016 | — | IC50 | = | 56390.0 | nM | 4.25 |
| CHEMBL2089131 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2089128 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2089127 | — | IC50 | > | 100000.0 | nM | - |