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Assay Detail

CHEMBL2091787

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CAMA-1
Confidence 1 — Organism
Curated By Autocuration

Target

CAMA-1 (CHEMBL1075416)
Type CELL-LINE
Organism Homo sapiens

Publication

A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells.
Onen-Bayram FE, Durmaz I, Scherman D, Herscovici J, Cetin-Atalay R.
Bioorg Med Chem (2012) 20 : 5094 -5102
PubMed 22867707 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 7.02 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2087602 1 8.00
CHEMBL65 CAMPTOTHECIN -1.0 1 7.16
CHEMBL185 FLUOROURACIL 4.0 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2087602 IC50 = 10.0 nM 8.00
CHEMBL65 CAMPTOTHECIN IC50 = 70.0 nM 7.16
CHEMBL185 FLUOROURACIL IC50 = 1280.0 nM 5.89