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Assay Detail

CHEMBL2114000

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
OSM: Inhibition of Plasmodium falciparum 3D7 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith.
ChEMBL ↗
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum 3D7
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
Vicky Avery (a), Jonathan Baell (b), Sanjay Batra (c), Jeremy Burrows (d), Soumya Bhattacharyya (c), Felix Calderon (e), Sue Charman(b), James R. Cronshaw (g), Sergio Wittlin (f), Matin Dean (g), Sandra Duffy (a), Sabine Fletcher (a), Javier Gamo (e), Zoe Hungerford (g), James Pham (h), Stuart Ralph (h), Murray N. Robertson (g), Matthew Tarnowski (g), Matthew H. Todd (g), Alice E. Williamson (g), Paul Willis (d), Karen White (b), Laura White (g), Paul M.Ylioja (g). (a) Discovery Biology, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD 4111, Australia; (b) Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia; (c) Medicinal Chemistry Division, Central Drug Research Institute, PO Box 173, Lucknow, 226 001, India; (d) Medicines for Malaria Venture, PO Box 1826, 20 rte de Pré-Bois, 1215 Geneva 15, Switzerland; (e) Tres Cantos Medicines Development Campus, Diseases of the Developing World (DDW), GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain; (f) Swiss Tropical and Public Health Institute, Socinstr. 57, 4051 Basel, Switzerland; (g) School of Chemistry, The University of Sydney, NSW 2006, Australia; (h) Department of Biochemistry & Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia.

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 71 6.49 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2113939 — — 1 9.00
CHEMBL2113938 — — 1 8.70
CHEMBL35228 PYRONARIDINE 3.0 1 8.49
CHEMBL207990 EPOXOMYCIN — 1 8.38
CHEMBL36 PYRIMETHAMINE 4.0 1 8.05
CHEMBL2113942 — — 1 7.92
CHEMBL2113937 — — 1 7.82
CHEMBL76 CHLOROQUINE 4.0 1 7.82
CHEMBL599702 — — 1 7.58
CHEMBL2113948 — — 1 7.47
CHEMBL2113926 — — 1 7.33
CHEMBL2113947 — — 1 7.27
CHEMBL2113944 — — 1 7.20
CHEMBL2113943 — — 1 6.77
CHEMBL2113927 — — 1 6.75
CHEMBL2113946 — — 1 6.51
CHEMBL2113945 — — 1 6.49
CHEMBL2113951 — — 1 6.48
CHEMBL533269 — — 1 6.46
CHEMBL549220 — — 1 6.39
CHEMBL2113961 — — 1 6.36
CHEMBL2113941 — — 1 5.51
CHEMBL2113988 — — 1 5.32
CHEMBL2113998 — — 1 5.11
CHEMBL2113976 — — 1 5.03
CHEMBL2113964 — — 1 5.03
CHEMBL2113984 — — 1 4.95
CHEMBL2113924 — — 1 4.92
CHEMBL2113981 — — 1 4.83
CHEMBL2113968 — — 1 4.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2113939 — IC50 = 1.0 nM 9.00
CHEMBL2113938 — IC50 = 2.0 nM 8.70
CHEMBL35228 PYRONARIDINE IC50 = 3.2 nM 8.49
CHEMBL207990 EPOXOMYCIN IC50 = 4.2 nM 8.38
CHEMBL36 PYRIMETHAMINE IC50 = 8.95 nM 8.05
CHEMBL2113942 — IC50 = 12.0 nM 7.92
CHEMBL2113937 — IC50 = 15.0 nM 7.82
CHEMBL76 CHLOROQUINE IC50 = 15.0 nM 7.82
CHEMBL599702 — IC50 = 26.0 nM 7.58
CHEMBL2113948 — IC50 = 34.0 nM 7.47
CHEMBL2113926 — IC50 = 47.0 nM 7.33
CHEMBL2113947 — IC50 = 54.0 nM 7.27
CHEMBL2113944 — IC50 = 63.0 nM 7.20
CHEMBL2113943 — IC50 = 169.0 nM 6.77
CHEMBL2113927 — IC50 = 176.0 nM 6.75
CHEMBL2113946 — IC50 = 307.0 nM 6.51
CHEMBL2113945 — IC50 = 326.0 nM 6.49
CHEMBL2113951 — IC50 = 333.0 nM 6.48
CHEMBL533269 — IC50 = 345.0 nM 6.46
CHEMBL549220 — IC50 = 404.0 nM 6.39
CHEMBL2113961 — IC50 = 438.0 nM 6.36
CHEMBL2113941 — IC50 = 3120.0 nM 5.51
CHEMBL2113988 — IC50 = 4800.0 nM 5.32
CHEMBL2113998 — IC50 = 7800.0 nM 5.11
CHEMBL2113964 — IC50 = 9400.0 nM 5.03
CHEMBL2113976 — IC50 = 9400.0 nM 5.03
CHEMBL2113984 — IC50 = 11300.0 nM 4.95
CHEMBL2113924 — IC50 = 11960.0 nM 4.92
CHEMBL2113981 — IC50 = 14700.0 nM 4.83
CHEMBL2113968 — IC50 = 17600.0 nM 4.75
CHEMBL2113982 — IC50 = 24700.0 nM 4.61
CHEMBL2113932 — IC50 = 31000.0 nM 4.51
CHEMBL269671 ARTEMISININ IC50 = 41063.0 nM 4.39
CHEMBL11360 — IC50 > 40000.0 nM -
CHEMBL2113993 — IC50 > 40000.0 nM -
CHEMBL2113992 — IC50 > 40000.0 nM -
CHEMBL2113922 — IC50 > 40000.0 nM -
CHEMBL2113991 — IC50 > 40000.0 nM -
CHEMBL2113990 — IC50 > 40000.0 nM -
CHEMBL2113989 — IC50 > 40000.0 nM -
CHEMBL2113986 — IC50 > 40000.0 nM -
CHEMBL2113985 — IC50 > 40000.0 nM -
CHEMBL2113994 — IC50 > 40000.0 nM -
CHEMBL2113997 — IC50 > 40000.0 nM -
CHEMBL2113983 — IC50 > 40000.0 nM -
CHEMBL2113979 — IC50 > 40000.0 nM -
CHEMBL1494650 — IC50 > 40000.0 nM -
CHEMBL2113977 — IC50 > 40000.0 nM -
CHEMBL2113972 — IC50 > 40000.0 nM -
CHEMBL2113996 — IC50 > 40000.0 nM -