Assay Detail
Functional
CHEMBL2114001
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OSM: Inhibition of Plasmodium falciparum 3D7 growth using a SYBR green I fluorescence based assay. Dose response curves were generated comprising of 8 points using a 2-fold serial dilution for the maximum final concentration of 1000 nM. Ralph Group, Bio21.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum 3D7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.17 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113939 | — | — | 1 | 8.30 |
| CHEMBL2113942 | — | — | 1 | 8.10 |
| CHEMBL2113937 | — | — | 1 | 8.05 |
| CHEMBL599702 | — | — | 1 | 7.96 |
| CHEMBL2113944 | — | — | 1 | 7.55 |
| CHEMBL2113945 | — | — | 1 | 6.81 |
| CHEMBL2113938 | — | — | 1 | 6.69 |
| CHEMBL2113943 | — | — | 1 | 6.47 |
| CHEMBL2113946 | — | — | 1 | 6.36 |
| CHEMBL2113947 | — | — | 1 | 6.31 |
| CHEMBL2113948 | — | — | 1 | 6.28 |
| CHEMBL2113931 | — | — | 1 | - |
| CHEMBL2113932 | — | — | 1 | - |
| CHEMBL2113940 | — | — | 1 | - |
| CHEMBL2113941 | — | — | 1 | - |
| CHEMBL1363033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113939 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2113942 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2113937 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL599702 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2113944 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2113945 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL2113938 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL2113943 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL2113946 | — | IC50 | = | 442.0 | nM | 6.36 |
| CHEMBL2113947 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL2113948 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2113931 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2113932 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2113940 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2113941 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1363033 | — | IC50 | > | 1000.0 | nM | - |