Assay Detail
Functional
CHEMBL2114020
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OSM: Inhibition of Plasmodium falciparum K1 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum K1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 9.00 |
| CHEMBL207990 | EPOXOMYCIN | — | 1 | 8.55 |
| CHEMBL2113926 | — | — | 1 | 7.18 |
| CHEMBL533269 | — | — | 1 | 6.82 |
| CHEMBL2113927 | — | — | 1 | 6.44 |
| CHEMBL549220 | — | — | 1 | 6.43 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.92 |
| CHEMBL2113924 | — | — | 1 | 4.91 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL207990 | EPOXOMYCIN | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2113926 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL533269 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL2113927 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL549220 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL2113924 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL76 | CHLOROQUINE | IC50 | 266.0 | nM | - |