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Assay Detail

CHEMBL2114776

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen. Follow-up assay.. (Class of assay: confirmatory)
ChEMBL ↗
83
Total Activities
83
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

ATP-dependent translocase ABCB1 (CHEMBL4302) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 83 10.04 10.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2134144 — — 1 10.99
CHEMBL2136603 — — 1 10.99
CHEMBL2138767 — — 1 10.98
CHEMBL2132650 — — 1 10.98
CHEMBL2132526 — — 1 10.96
CHEMBL2136710 — — 1 10.93
CHEMBL2137849 — — 1 10.93
CHEMBL1900518 — — 1 10.89
CHEMBL2135811 — — 1 10.87
CHEMBL2132316 — — 1 10.87
CHEMBL2141711 — — 1 10.83
CHEMBL2142519 — — 1 10.81
CHEMBL2136218 — — 1 10.80
CHEMBL2142058 — — 1 10.80
CHEMBL2137696 — — 1 10.78
CHEMBL2139052 — — 1 10.77
CHEMBL1884699 — — 1 10.76
CHEMBL2134880 — — 1 10.76
CHEMBL2138028 — — 1 10.75
CHEMBL2137680 — — 1 10.74
CHEMBL2135227 — — 1 10.74
CHEMBL2132333 — — 1 10.71
CHEMBL2135699 — — 1 10.71
CHEMBL2145384 — — 1 10.66
CHEMBL2133117 — — 1 10.63
CHEMBL2138719 — — 1 10.57
CHEMBL2141371 — — 1 10.56
CHEMBL2140166 — — 1 10.54
CHEMBL2140410 — — 1 10.49
CHEMBL2134322 — — 1 10.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2134144 — EC50 = 0.01015 nM 10.99
CHEMBL2136603 — EC50 = 0.01026 nM 10.99
CHEMBL2132650 — EC50 = 0.01046 nM 10.98
CHEMBL2138767 — EC50 = 0.01057 nM 10.98
CHEMBL2132526 — EC50 = 0.01096 nM 10.96
CHEMBL2136710 — EC50 = 0.01184 nM 10.93
CHEMBL2137849 — EC50 = 0.01177 nM 10.93
CHEMBL1900518 — EC50 = 0.01283 nM 10.89
CHEMBL2135811 — EC50 = 0.01349 nM 10.87
CHEMBL2132316 — EC50 = 0.01351 nM 10.87
CHEMBL2141711 — EC50 = 0.01481 nM 10.83
CHEMBL2142519 — EC50 = 0.01533 nM 10.81
CHEMBL2136218 — EC50 = 0.01574 nM 10.80
CHEMBL2142058 — EC50 = 0.01582 nM 10.80
CHEMBL2137696 — EC50 = 0.01661 nM 10.78
CHEMBL2139052 — EC50 = 0.01686 nM 10.77
CHEMBL1884699 — EC50 = 0.01727 nM 10.76
CHEMBL2134880 — EC50 = 0.0175 nM 10.76
CHEMBL2138028 — EC50 = 0.01797 nM 10.75
CHEMBL2137680 — EC50 = 0.01824 nM 10.74
CHEMBL2135227 — EC50 = 0.01816 nM 10.74
CHEMBL2132333 — EC50 = 0.01956 nM 10.71
CHEMBL2135699 — EC50 = 0.0196 nM 10.71
CHEMBL2145384 — EC50 = 0.02166 nM 10.66
CHEMBL2133117 — EC50 = 0.02338 nM 10.63
CHEMBL2138719 — EC50 = 0.02676 nM 10.57
CHEMBL2141371 — EC50 = 0.02749 nM 10.56
CHEMBL2140166 — EC50 = 0.02882 nM 10.54
CHEMBL2140410 — EC50 = 0.03209 nM 10.49
CHEMBL2134322 — EC50 = 0.03638 nM 10.44
CHEMBL2137688 — EC50 = 0.05729 nM 10.24
CHEMBL2144131 — EC50 = 0.06041 nM 10.22
CHEMBL2139235 — EC50 = 0.06117 nM 10.21
CHEMBL2142245 — EC50 = 0.06443 nM 10.19
CHEMBL2130718 — EC50 = 0.1261 nM 9.90
CHEMBL2133411 — EC50 = 0.1443 nM 9.84
CHEMBL2132529 — EC50 = 0.1432 nM 9.84
CHEMBL2133727 — EC50 = 0.1485 nM 9.83
CHEMBL2142216 — EC50 = 0.1524 nM 9.82
CHEMBL2137928 — EC50 = 0.1832 nM 9.74
CHEMBL2132766 — EC50 = 0.2157 nM 9.67
CHEMBL2139350 — EC50 = 0.2986 nM 9.53
CHEMBL2133413 — EC50 = 0.5212 nM 9.28
CHEMBL2143184 — EC50 = 0.5509 nM 9.26
CHEMBL2138502 — EC50 = 0.6234 nM 9.21
CHEMBL1325873 — EC50 = 0.6526 nM 9.19
CHEMBL2131986 — EC50 = 0.9231 nM 9.04
CHEMBL2139757 — EC50 = 1.507 nM 8.82
CHEMBL2136204 — EC50 = 4.725 nM 8.33
CHEMBL2130929 — EC50 = 4.997 nM 8.30