Assay Detail
Binding
CHEMBL2148241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]PDBu binding to PKCepsilon C1B domain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.32 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2148106 | DEBROMOAPLYSIATOXIN | — | 1 | 9.20 |
| CHEMBL2148108 | — | — | 1 | 8.70 |
| CHEMBL2148107 | — | — | 1 | 7.77 |
| CHEMBL1258348 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2148106 | DEBROMOAPLYSIATOXIN | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL2148108 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2148107 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1258348 | — | Ki | = | 25.0 | nM | 7.60 |