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Assay Detail

CHEMBL2148481

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IL-5 in mouse Y16 cells after 48 hrs by WST1 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type Y16
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Interleukin-5 (CHEMBL1163111)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Novel interleukin-5 inhibitors based on hydroxyethylaminomethyl-4H-chromen-4-one scaffold.
Joo C, Venkateswararao E, Lee KC, Sharma VK, Kyung MS, Kim Y, Jung SH.
Bioorg Med Chem (2012) 20 : 5757 -5762
PubMed 22954899 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.89 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2146491 1 5.05
CHEMBL2147495 1 5.05
CHEMBL2147499 1 5.04
CHEMBL2147492 1 5.04
CHEMBL2147498 1 5.03
CHEMBL2147500 1 4.99
CHEMBL2147493 1 4.99
CHEMBL486626 SOPHORICOSIDE 1 4.97
CHEMBL2147496 1 4.91
CHEMBL2147501 1 4.85
CHEMBL2147494 1 4.84
CHEMBL2147491 1 4.81
CHEMBL2147497 1 4.79
CHEMBL2147490 1 4.71
CHEMBL1370 BUDESONIDE 4.0 1 4.57
CHEMBL2147489 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2146491 IC50 = 9000.0 nM 5.05
CHEMBL2147495 IC50 = 9000.0 nM 5.05
CHEMBL2147499 IC50 = 9100.0 nM 5.04
CHEMBL2147492 IC50 = 9200.0 nM 5.04
CHEMBL2147498 IC50 = 9400.0 nM 5.03
CHEMBL2147500 IC50 = 10300.0 nM 4.99
CHEMBL2147493 IC50 = 10200.0 nM 4.99
CHEMBL486626 SOPHORICOSIDE IC50 = 10600.0 nM 4.97
CHEMBL2147496 IC50 = 12400.0 nM 4.91
CHEMBL2147501 IC50 = 14200.0 nM 4.85
CHEMBL2147494 IC50 = 14300.0 nM 4.84
CHEMBL2147491 IC50 = 15400.0 nM 4.81
CHEMBL2147497 IC50 = 16100.0 nM 4.79
CHEMBL2147490 IC50 = 19500.0 nM 4.71
CHEMBL1370 BUDESONIDE IC50 = 27100.0 nM 4.57
CHEMBL2147489 IC50 = 30300.0 nM 4.52