Assay Detail
Binding
CHEMBL2148512
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Inhibition of PRL1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein tyrosine phosphatase type IVA 1 (CHEMBL1075169) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.59 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2146958 | — | — | 1 | 4.85 |
| CHEMBL2146956 | — | — | 1 | 4.68 |
| CHEMBL2146957 | — | — | 1 | 4.43 |
| CHEMBL2057830 | — | — | 1 | 4.40 |
| CHEMBL399586 | — | — | 1 | - |
| CHEMBL2146959 | — | — | 1 | - |
| CHEMBL2146960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2146958 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2146956 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2146957 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL2057830 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL399586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2146959 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2146960 | — | IC50 | > | 100000.0 | nM | - |