Assay Detail
Binding
CHEMBL2148658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Albino Wistar rat CaMK2 in postsynaptic density fraction using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.73 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 5.44 |
| CHEMBL181529 | — | — | 1 | 4.64 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.10 |
| CHEMBL258741 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL181529 | — | IC50 | = | 22870.0 | nM | 4.64 |
| CHEMBL140 | CURCUMIN | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL258741 | — | IC50 | = | 103000.0 | nM | - |