Assay Detail
Binding
CHEMBL2148659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Albino Wistar rat CaMK2 autophosphorylation at Thr286 in brain cytosolic fraction using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.55 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 4.79 |
| CHEMBL181529 | — | — | 1 | 4.77 |
| CHEMBL258741 | — | — | 1 | 4.10 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 16320.0 | nM | 4.79 |
| CHEMBL181529 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL258741 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL140 | CURCUMIN | IC50 | = | 143000.0 | nM | - |