Assay Detail
Binding
CHEMBL2148933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CHEMBL4147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.83 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 5.83 |
| CHEMBL181529 | — | — | 1 | 4.94 |
| CHEMBL140 | CURCUMIN | 3.0 | 2 | 4.89 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | — | 1 | 4.62 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | — | 1 | 4.43 |
| CHEMBL258741 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL181529 | — | IC50 | = | 11370.0 | nM | 4.94 |
| CHEMBL140 | CURCUMIN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL140 | CURCUMIN | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL258741 | — | IC50 | = | 37000.0 | nM | 4.43 |