Assay Detail
Functional
CHEMBL2150101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship (SAR) study of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the potential of the lead against multidrug resistance in cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.06 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 10.00 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.77 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.36 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 6.29 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.64 |
| CHEMBL2147958 | — | — | 1 | 5.63 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 4.85 |
| CHEMBL1915706 | — | — | 1 | 4.57 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2147958 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL803 | CYTARABINE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1915706 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL376408 | ABT 737 | IC50 | = | 34700.0 | nM | 4.46 |