Assay Detail
Functional
CHEMBL2153947
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Antiproliferative activity against human KB cells after 48 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mechanism-based design, synthesis and biological studies of N⁵-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.18 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153710 | — | — | 1 | 6.47 |
| CHEMBL2153707 | — | — | 1 | 5.57 |
| CHEMBL2153703 | — | — | 1 | 5.17 |
| CHEMBL2153712 | — | — | 1 | 4.70 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 4.68 |
| CHEMBL2151066 | — | — | 1 | 4.51 |
| CHEMBL2153705 | — | — | 1 | - |
| CHEMBL2153704 | — | — | 1 | - |
| CHEMBL2153706 | — | — | 1 | - |
| CHEMBL2153708 | — | — | 1 | - |
| CHEMBL2153711 | — | — | 1 | - |
| CHEMBL2153713 | — | — | 1 | - |
| CHEMBL2153714 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153710 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL2153707 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2153703 | — | IC50 | = | 6722.0 | nM | 5.17 |
| CHEMBL2153712 | — | IC50 | = | 20030.0 | nM | 4.70 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL2151066 | — | IC50 | = | 31050.0 | nM | 4.51 |
| CHEMBL2153705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2153704 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2153706 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2153708 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2153711 | — | IC50 | > | 130000.0 | nM | - |
| CHEMBL2153713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2153714 | — | IC50 | > | 100000.0 | nM | - |