Assay Detail
Functional
CHEMBL2153948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Bel7402 cells after 48 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mechanism-based design, synthesis and biological studies of N⁵-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.79 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153710 | — | — | 1 | 6.49 |
| CHEMBL2153712 | — | — | 1 | 4.91 |
| CHEMBL2153707 | — | — | 1 | 4.74 |
| CHEMBL2153705 | — | — | 1 | 4.21 |
| CHEMBL2153704 | — | — | 1 | 4.19 |
| CHEMBL2153711 | — | — | 1 | 4.19 |
| CHEMBL2151066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153710 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL2153712 | — | IC50 | = | 12350.0 | nM | 4.91 |
| CHEMBL2153707 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL2153705 | — | IC50 | = | 61500.0 | nM | 4.21 |
| CHEMBL2153704 | — | IC50 | = | 64700.0 | nM | 4.19 |
| CHEMBL2153711 | — | IC50 | = | 65200.0 | nM | 4.19 |
| CHEMBL2151066 | — | IC50 | > | 100000.0 | nM | - |