Assay Detail
Binding
CHEMBL2154047
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Inhibition of human mPGES-1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Prostaglandin e2 synthase-1 inhibitors as potential treatment for osteoarthritis: patent highlight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.47 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152710 | — | — | 1 | 6.75 |
| CHEMBL2152712 | LY-3031207 | 1.0 | 1 | 6.62 |
| CHEMBL2152711 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152710 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2152712 | LY-3031207 | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2152711 | — | IC50 | = | 890.0 | nM | 6.05 |