Assay Detail
Binding
CHEMBL2154062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus DNA topoisomerase 4 Par E subunit by ATPase assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA topoisomerase 4 subunit B (CHEMBL2150841) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors: Patent Highlight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.72 | 7.92 |
| IC50 | 1 | 6.82 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152855 | — | — | 1 | 7.92 |
| CHEMBL2152856 | — | — | 2 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152855 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2152856 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2152856 | — | IC50 | = | 150.0 | nM | 6.82 |