Assay Detail
Binding
CHEMBL2154067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of gamma-secretase-mediated amyloid beta-42 production in diluted 2B7 conditioned media after 5 hrs
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.63 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152870 | — | — | 1 | 7.26 |
| CHEMBL2152893 | — | — | 1 | 7.22 |
| CHEMBL2152863 | — | — | 1 | 7.22 |
| CHEMBL2152897 | — | — | 1 | 7.16 |
| CHEMBL2152892 | — | — | 1 | 7.10 |
| CHEMBL2152896 | — | — | 1 | 7.10 |
| CHEMBL2152894 | — | — | 1 | 7.05 |
| CHEMBL2152882 | — | — | 1 | 7.05 |
| CHEMBL2152867 | — | — | 1 | 7.00 |
| CHEMBL2152860 | — | — | 1 | 7.00 |
| CHEMBL2152883 | — | — | 1 | 6.96 |
| CHEMBL2152891 | — | — | 1 | 6.92 |
| CHEMBL2152890 | — | — | 1 | 6.92 |
| CHEMBL2152898 | — | — | 1 | 6.89 |
| CHEMBL2152869 | — | — | 1 | 6.89 |
| CHEMBL2152895 | — | — | 1 | 6.89 |
| CHEMBL2152886 | — | — | 1 | 6.85 |
| CHEMBL2152885 | — | — | 1 | 6.82 |
| CHEMBL2152884 | — | — | 1 | 6.80 |
| CHEMBL2152880 | — | — | 1 | 6.77 |
| CHEMBL2152881 | — | — | 1 | 6.75 |
| CHEMBL2152871 | — | — | 1 | 6.72 |
| CHEMBL2152889 | — | — | 1 | 6.70 |
| CHEMBL2152879 | — | — | 1 | 6.68 |
| CHEMBL2152878 | — | — | 1 | 6.64 |
| CHEMBL2152877 | — | — | 1 | 6.62 |
| CHEMBL2152875 | — | — | 1 | 6.46 |
| CHEMBL2152887 | — | — | 1 | 6.43 |
| CHEMBL2152888 | — | — | 1 | 6.31 |
| CHEMBL2152862 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152870 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2152893 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2152863 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2152897 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2152892 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2152896 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2152894 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2152882 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2152867 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2152860 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2152883 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2152891 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2152890 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2152895 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2152869 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2152898 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2152886 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2152885 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2152884 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2152880 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2152881 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2152871 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2152889 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2152879 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2152878 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2152877 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2152875 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2152887 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2152888 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2152862 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2152865 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2152872 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2152874 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2152876 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL2152873 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2152868 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2152861 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2152864 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2152866 | — | IC50 | > | 10000.0 | nM | - |