Assay Detail
Binding
CHEMBL2154068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of gamma-secretase-mediated amyloid beta-40 production in diluted 2B7 conditioned media after 5 hrs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.18 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152863 | — | — | 1 | 6.00 |
| CHEMBL2152870 | — | — | 1 | 5.85 |
| CHEMBL2152860 | — | — | 1 | 5.57 |
| CHEMBL2152869 | — | — | 1 | 5.47 |
| CHEMBL2152897 | — | — | 1 | 5.32 |
| CHEMBL2152889 | — | — | 1 | 5.16 |
| CHEMBL2152879 | — | — | 1 | 5.12 |
| CHEMBL2152885 | — | — | 1 | 5.11 |
| CHEMBL2152896 | — | — | 1 | 5.10 |
| CHEMBL2152886 | — | — | 1 | 5.05 |
| CHEMBL2152878 | — | — | 1 | 5.03 |
| CHEMBL2152894 | — | — | 1 | 4.87 |
| CHEMBL2152887 | — | — | 1 | 4.85 |
| CHEMBL2152880 | — | — | 1 | 4.85 |
| CHEMBL2152872 | — | — | 1 | 4.80 |
| CHEMBL2152888 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152863 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2152870 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2152860 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2152869 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2152897 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2152889 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2152879 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2152885 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2152896 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2152886 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2152878 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL2152894 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL2152887 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2152880 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL2152872 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL2152888 | — | IC50 | = | 18800.0 | nM | 4.73 |