Assay Detail
Binding
CHEMBL2154183
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Inhibition of BACE1 by diluted TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
BACE Inhibitors: Potential Treatment of Alzheimer's Disease, Dementia, and Related Neurodegenerative Disorders (B): 3-Amino-4-fluoro-1H-isoindol Derivatives: Patent Highlight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152903 | — | — | 1 | 8.70 |
| CHEMBL2152906 | — | — | 1 | 8.30 |
| CHEMBL2152905 | — | — | 1 | 8.22 |
| CHEMBL2152904 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152903 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2152906 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2152905 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2152904 | — | IC50 | = | 8.0 | nM | 8.10 |