Assay Detail
Binding
CHEMBL2154188
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Inhibition of BACE by TR-FRET assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Compounds and Their Use as BACE Inhibitors: Patent Highlight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.64 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152921 | — | — | 1 | 9.14 |
| CHEMBL2151058 | — | — | 1 | 8.85 |
| CHEMBL2152919 | — | — | 1 | 8.85 |
| CHEMBL2152915 | — | — | 1 | 8.80 |
| CHEMBL2152918 | — | — | 1 | 8.80 |
| CHEMBL2152914 | — | — | 1 | 8.66 |
| CHEMBL2152920 | — | — | 1 | 8.64 |
| CHEMBL2152916 | — | — | 1 | 8.32 |
| CHEMBL2152917 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152921 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL2151058 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2152919 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2152915 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2152918 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2152914 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2152920 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2152916 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2152917 | — | IC50 | = | 20.0 | nM | 7.70 |