Assay Detail

CHEMBL2154229

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Functional

Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay

ChEMBL ↗

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Target

MDA-MB-231 (CHEMBL400) ↗

Open DB target context

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MDA-MB-231 (CHEMBL400) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-MB-231

CHEMBL400

Anchored from Assay target.

Protein identity MDA-MB-231

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-MB-231
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives.

Gurkan-Alp AS, Mumcuoglu M, Andac CA, Dayanc E, Cetin-Atalay R, Buyukbingol E.
Eur J Med Chem (2012) 58 : 346 -354
PubMed 23142674 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.74	5.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2153844	—	—	1	5.74
CHEMBL65	CAMPTOTHECIN	-1.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2153844	—	IC50	=	1830.0	nM	5.74
CHEMBL65	CAMPTOTHECIN	IC50	<	10.0	nM	-