Assay Detail
Functional
CHEMBL2154367
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Antagonist activity at hyperpolarized T-type calcium channel by FLIPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.37 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151145 | — | — | 1 | 6.69 |
| CHEMBL2151144 | — | — | 1 | 6.60 |
| CHEMBL1684954 | — | — | 1 | 6.42 |
| CHEMBL2151146 | — | — | 1 | 6.40 |
| CHEMBL2151147 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151145 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL2151144 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL1684954 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL2151146 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL2151147 | — | IC50 | = | 1918.0 | nM | 5.72 |