Assay Detail
Binding
CHEMBL2154958
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Binding affinity to human histamine H1 receptor
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histamine H3 receptor as a drug discovery target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.36 | 8.15 |
| Kd | 2 | 9.29 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 10.06 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.51 |
| CHEMBL292195 | — | — | 1 | 8.15 |
| CHEMBL2151156 | — | — | 1 | 7.90 |
| CHEMBL1767164 | GSK-1004723 | 2.0 | 1 | 7.80 |
| CHEMBL2151155 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Kd | = | 0.087 | nM | 10.06 |
| CHEMBL42 | CLOZAPINE | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL292195 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL2151156 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1767164 | GSK-1004723 | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL2151155 | — | Ki | = | 2511.89 | nM | 5.60 |