Assay Detail
Functional
CHEMBL2155124
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Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.19 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152070 | — | — | 1 | 6.15 |
| CHEMBL2151298 | — | — | 1 | 5.72 |
| CHEMBL2152071 | — | — | 1 | 4.47 |
| CHEMBL2152069 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152070 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2151298 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2152071 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2152069 | — | EC50 | = | 38000.0 | nM | 4.42 |