Assay Detail
Binding
CHEMBL2155208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TGM2
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-glutamine gamma-glutamyltransferase (CHEMBL2730) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.12 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152204 | — | — | 1 | 6.96 |
| CHEMBL2152105 | — | — | 1 | 6.85 |
| CHEMBL2152213 | — | — | 1 | 6.77 |
| CHEMBL2152199 | — | — | 1 | 6.77 |
| CHEMBL2152214 | — | — | 1 | 6.75 |
| CHEMBL2152098 | — | — | 1 | 6.75 |
| CHEMBL2152201 | — | — | 1 | 6.70 |
| CHEMBL2152099 | — | — | 1 | 6.70 |
| CHEMBL2152209 | — | — | 1 | 6.64 |
| CHEMBL2152212 | — | — | 1 | 6.58 |
| CHEMBL2152207 | — | — | 1 | 6.55 |
| CHEMBL2152203 | — | — | 1 | 6.55 |
| CHEMBL2152211 | — | — | 1 | 6.55 |
| CHEMBL2152090 | — | — | 1 | 6.55 |
| CHEMBL2152208 | — | — | 1 | 6.51 |
| CHEMBL2152200 | — | — | 1 | 6.50 |
| CHEMBL2152197 | — | — | 1 | 6.44 |
| CHEMBL2152198 | — | — | 1 | 6.42 |
| CHEMBL2152101 | — | — | 1 | 6.39 |
| CHEMBL2152103 | — | — | 1 | 6.34 |
| CHEMBL2152210 | — | — | 1 | 6.34 |
| CHEMBL2152202 | — | — | 1 | 6.26 |
| CHEMBL2152102 | — | — | 1 | 6.21 |
| CHEMBL2152104 | — | — | 1 | 6.20 |
| CHEMBL2152196 | — | — | 1 | 6.18 |
| CHEMBL2152100 | — | — | 1 | 6.11 |
| CHEMBL2152216 | — | — | 1 | 5.80 |
| CHEMBL2152097 | — | — | 1 | 5.80 |
| CHEMBL2086885 | — | — | 1 | 5.54 |
| CHEMBL2152092 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152204 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2152105 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2152199 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2152213 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2152214 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2152098 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2152201 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2152099 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2152209 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2152212 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2152203 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2152090 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2152211 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2152207 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2152208 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2152200 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2152197 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2152198 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2152101 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2152103 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2152210 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2152202 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2152102 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2152104 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2152196 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2152100 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2152216 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2152097 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2086885 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2152092 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2152091 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2152215 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2152205 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2152096 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2152095 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL2152206 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL2152094 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL2152093 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL2086886 | — | IC50 | > | 80000.0 | nM | - |