Assay Detail
Binding
CHEMBL2155279
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Inhibition of mouse 11betaHSD1 by scintillation proximity assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.28 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152223 | — | — | 1 | 8.89 |
| CHEMBL2152237 | — | — | 1 | 7.96 |
| CHEMBL2152227 | — | — | 1 | 7.20 |
| CHEMBL2152222 | — | — | 1 | 7.19 |
| CHEMBL2152243 | — | — | 1 | 7.06 |
| CHEMBL2152236 | — | — | 1 | 7.01 |
| CHEMBL2152235 | — | — | 1 | 6.95 |
| CHEMBL2152231 | — | — | 1 | 6.90 |
| CHEMBL2152230 | — | — | 1 | 6.84 |
| CHEMBL2152242 | — | — | 1 | 6.79 |
| CHEMBL2152225 | — | — | 1 | - |
| CHEMBL2152226 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152223 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2152237 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2152227 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2152222 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL2152243 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL2152236 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2152235 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL2152231 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2152230 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL2152242 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL2152225 | — | IC50 | - | — | - | |
| CHEMBL2152226 | — | IC50 | - | — | - |