Assay Detail
Binding
CHEMBL2155333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GST-tagged CDK5/p25 expressed in Escherichia coli using histone H1 as substrate and [gamma32P]ATP after 30 mins by scintillation counting
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.28 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836358 | — | — | 1 | 5.28 |
| CHEMBL2153545 | — | — | 1 | - |
| CHEMBL2153521 | — | — | 1 | - |
| CHEMBL2153520 | — | — | 1 | - |
| CHEMBL2153519 | — | — | 1 | - |
| CHEMBL2153518 | — | — | 1 | - |
| CHEMBL2153411 | — | — | 1 | - |
| CHEMBL2153412 | — | — | 1 | - |
| CHEMBL2153515 | — | — | 1 | - |
| CHEMBL2153516 | — | — | 1 | - |
| CHEMBL2153522 | — | — | 1 | - |
| CHEMBL2153550 | — | — | 1 | - |
| CHEMBL2153549 | — | — | 1 | - |
| CHEMBL2153548 | — | — | 1 | - |
| CHEMBL2153547 | — | — | 1 | - |
| CHEMBL2153546 | — | — | 1 | - |
| CHEMBL2153544 | — | — | 1 | - |
| CHEMBL2153543 | — | — | 1 | - |
| CHEMBL2153531 | — | — | 1 | - |
| CHEMBL2153541 | — | — | 1 | - |
| CHEMBL2153540 | — | — | 1 | - |
| CHEMBL2153539 | — | — | 1 | - |
| CHEMBL2153538 | — | — | 1 | - |
| CHEMBL2153537 | — | — | 1 | - |
| CHEMBL2153536 | — | — | 1 | - |
| CHEMBL2153535 | — | — | 1 | - |
| CHEMBL2153534 | — | — | 1 | - |
| CHEMBL2153533 | — | — | 1 | - |
| CHEMBL2153532 | — | — | 1 | - |
| CHEMBL2153542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836358 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL457313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153522 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153516 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153515 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153412 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153411 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153518 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153519 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153520 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153521 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153550 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153523 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153524 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153527 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153528 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153529 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153530 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153542 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153533 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153534 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153535 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153536 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153537 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153538 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153531 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153544 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153545 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2153548 | — | IC50 | > | 10000.0 | nM | - |