Assay Detail
Binding
CHEMBL2155356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant renin compound treated for 10 mins before substrate addition measured after 90 mins by fluorescence method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.94 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152353 | — | — | 1 | 9.05 |
| CHEMBL3545059 | ALISKIREN FUMARATE | 4.0 | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152353 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3545059 | ALISKIREN FUMARATE | IC50 | = | 1.5 | nM | 8.82 |