Assay Detail
Binding
CHEMBL2155358
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Inhibition of cynomolgus monkey plasma renin activity after 60 mins by competitive RIA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca fascicularis |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.15 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152353 | — | — | 1 | 8.20 |
| CHEMBL3545059 | ALISKIREN FUMARATE | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152353 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3545059 | ALISKIREN FUMARATE | IC50 | = | 8.0 | nM | 8.10 |