Assay Detail
Binding
CHEMBL2155446
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Inhibition of gamma secretase assessed as reduction in Abeta42 production
127
Total Activities
127
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 127 | 6.83 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151221 | — | — | 1 | 8.70 |
| CHEMBL2151309 | — | — | 1 | 8.40 |
| CHEMBL2151107 | — | — | 1 | 8.30 |
| CHEMBL2151219 | — | — | 1 | 8.30 |
| CHEMBL2151164 | — | — | 1 | 8.22 |
| CHEMBL2151308 | — | — | 1 | 8.22 |
| CHEMBL2151306 | — | — | 1 | 8.10 |
| CHEMBL2151165 | — | — | 1 | 8.05 |
| CHEMBL2151220 | — | — | 1 | 8.00 |
| CHEMBL2151159 | — | — | 1 | 7.96 |
| CHEMBL2151204 | — | — | 1 | 7.96 |
| CHEMBL2151307 | — | — | 1 | 7.96 |
| CHEMBL2151116 | — | — | 1 | 7.92 |
| CHEMBL2151217 | — | — | 1 | 7.85 |
| CHEMBL2151202 | — | — | 1 | 7.85 |
| CHEMBL2151200 | — | — | 1 | 7.85 |
| CHEMBL2151111 | — | — | 1 | 7.80 |
| CHEMBL2151205 | E-2212 | 1.0 | 1 | 7.77 |
| CHEMBL2151113 | — | — | 1 | 7.75 |
| CHEMBL2151218 | — | — | 1 | 7.68 |
| CHEMBL2151230 | — | — | 1 | 7.68 |
| CHEMBL2151203 | — | — | 1 | 7.66 |
| CHEMBL2151176 | — | — | 1 | 7.66 |
| CHEMBL2151177 | — | — | 1 | 7.60 |
| CHEMBL2151198 | — | — | 1 | 7.55 |
| CHEMBL2151199 | — | — | 1 | 7.51 |
| CHEMBL2151106 | — | — | 1 | 7.48 |
| CHEMBL2151115 | — | — | 1 | 7.48 |
| CHEMBL2151201 | — | — | 1 | 7.43 |
| CHEMBL2151166 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151221 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2151309 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2151107 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2151219 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2151308 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2151164 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2151306 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2151165 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2151220 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2151307 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2151204 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2151159 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2151116 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2151202 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2151200 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2151217 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2151111 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2151205 | E-2212 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2151113 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2151230 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2151218 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2151176 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2151203 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2151177 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2151198 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2151199 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2151106 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2151115 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2151201 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2151166 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1915569 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2151108 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2151212 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2151109 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2151102 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2151103 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2151082 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2151085 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2151101 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2151171 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2151112 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2151110 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2151231 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2151068 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2151234 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2151229 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2151284 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2151215 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2151216 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2151277 | — | IC50 | = | 100.0 | nM | 7.00 |