Assay Detail
Functional
CHEMBL2156019
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.01 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 5.21 |
| CHEMBL2153504 | — | — | 1 | 5.20 |
| CHEMBL336253 | ADOCIAQUINONE A | — | 1 | 5.20 |
| CHEMBL2153503 | — | — | 1 | 5.19 |
| CHEMBL510492 | XESTOQUINONE | — | 1 | 4.69 |
| CHEMBL2153505 | — | — | 1 | 4.55 |
| CHEMBL1208027 | XESTOQUINOL SULFATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL2153504 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL336253 | ADOCIAQUINONE A | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL2153503 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL510492 | XESTOQUINONE | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL2153505 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL1208027 | XESTOQUINOL SULFATE | IC50 | > | 30000.0 | nM | - |