Assay Detail
Functional
CHEMBL2156038
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Cytotoxicity against human PC3 cells expressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Camptothecins in tumor homing via an RGD sequence mimetic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.14 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.59 |
| CHEMBL112769 | — | — | 1 | 7.82 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 7.11 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.73 |
| CHEMBL2153643 | — | — | 1 | 5.47 |
| CHEMBL2153644 | — | — | 1 | - |
| CHEMBL2153645 | — | — | 1 | - |
| CHEMBL2153646 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL112769 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL2153643 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2153644 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2153645 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2153646 | — | IC50 | > | 1000.0 | nM | - |