Assay Detail
Binding
CHEMBL2156175
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Binding affinity to human plasma antithrombin assessed as decrease in intrinsic tryptophan fluorescence by fluorescence spectroscopy
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.02 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200644 | FONDAPARINUX SODIUM | 4.0 | 1 | 9.00 |
| CHEMBL2151424 | — | — | 1 | 4.98 |
| CHEMBL2151418 | — | — | 1 | 4.09 |
| CHEMBL2151416 | — | — | 1 | - |
| CHEMBL2151417 | — | — | 1 | - |
| CHEMBL2151419 | — | — | 1 | - |
| CHEMBL2151420 | — | — | 1 | - |
| CHEMBL2151421 | — | — | 1 | - |
| CHEMBL2151422 | — | — | 1 | - |
| CHEMBL2151423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200644 | FONDAPARINUX SODIUM | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL2151424 | — | Kd | = | 10500.0 | nM | 4.98 |
| CHEMBL2151418 | — | Kd | = | 81000.0 | nM | 4.09 |
| CHEMBL2151416 | — | Kd | = | 753000.0 | nM | - |
| CHEMBL2151417 | — | Kd | = | 1123000.0 | nM | - |
| CHEMBL2151419 | — | Kd | = | 273000.0 | nM | - |
| CHEMBL2151420 | — | Kd | = | 3883000.0 | nM | - |
| CHEMBL2151421 | — | Kd | = | 394000.0 | nM | - |
| CHEMBL2151422 | — | Kd | = | 420000.0 | nM | - |
| CHEMBL2151423 | — | Kd | = | 1322000.0 | nM | - |