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Assay Detail

CHEMBL2156199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives.
Csuk R, Schwarz S, Siewert B, Kluge R, Ströhl D.
Eur J Med Chem (2011) 46 : 5356 -5369
PubMed 21959232 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.00 5.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2151608 1 5.61
CHEMBL2151607 1 5.59
CHEMBL2151609 1 5.29
CHEMBL2151613 1 4.82
CHEMBL2151610 1 4.80
CHEMBL2151727 1 4.69
CHEMBL2151046 1 4.59
CHEMBL2151612 1 4.58
CHEMBL590534 1 -
CHEMBL1807165 1 -
CHEMBL2151606 1 -
CHEMBL2151611 1 -
CHEMBL2151726 1 -
CHEMBL2151728 1 -
CHEMBL2151729 1 -
CHEMBL2151730 1 -
CHEMBL2151731 1 -
CHEMBL493512 1 -
CHEMBL2151732 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2151608 IC50 = 2470.0 nM 5.61
CHEMBL2151607 IC50 = 2550.0 nM 5.59
CHEMBL2151609 IC50 = 5080.0 nM 5.29
CHEMBL2151613 IC50 = 15170.0 nM 4.82
CHEMBL2151610 IC50 = 15950.0 nM 4.80
CHEMBL2151727 IC50 = 20580.0 nM 4.69
CHEMBL2151046 IC50 = 25420.0 nM 4.59
CHEMBL2151612 IC50 = 26350.0 nM 4.58
CHEMBL590534 IC50 > 30000.0 nM -
CHEMBL1807165 IC50 > 30000.0 nM -
CHEMBL2151606 IC50 > 30000.0 nM -
CHEMBL2151611 IC50 > 30000.0 nM -
CHEMBL2151726 IC50 > 30000.0 nM -
CHEMBL2151728 IC50 > 30000.0 nM -
CHEMBL2151729 IC50 > 30000.0 nM -
CHEMBL2151730 IC50 > 30000.0 nM -
CHEMBL2151731 IC50 > 30000.0 nM -
CHEMBL493512 IC50 > 30000.0 nM -
CHEMBL2151732 IC50 > 30000.0 nM -