Assay Detail
Binding
CHEMBL2156476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of vitronectin binding to human alphaVbeta3 integrin expressed in PC3 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Camptothecins in tumor homing via an RGD sequence mimetic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.05 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153647 | — | — | 1 | 8.20 |
| CHEMBL2153643 | — | — | 1 | 7.43 |
| CHEMBL2153645 | — | — | 1 | 6.89 |
| CHEMBL2153644 | — | — | 1 | 6.46 |
| CHEMBL2153646 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153647 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL2153643 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2153645 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2153644 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2153646 | — | IC50 | = | 540.0 | nM | 6.27 |