Assay Detail
Binding
CHEMBL2157131
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Inhibition of 5-LOX
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Charting, navigating, and populating natural product chemical space for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.73 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152123 | — | — | 1 | 6.44 |
| CHEMBL149839 | — | — | 1 | 5.82 |
| CHEMBL1213616 | — | — | 1 | 5.52 |
| CHEMBL146439 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152123 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL149839 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1213616 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL146439 | — | IC50 | = | 7500.0 | nM | 5.12 |