Assay Detail
Binding
CHEMBL2157136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PI3Kdelta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.08 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152257 | — | — | 1 | 7.39 |
| CHEMBL2152139 | — | — | 1 | 7.00 |
| CHEMBL2152256 | — | — | 1 | 6.74 |
| CHEMBL2152148 | — | — | 1 | 6.47 |
| CHEMBL2152130 | — | — | 1 | 6.45 |
| CHEMBL2151050 | — | — | 1 | 6.41 |
| CHEMBL2152141 | — | — | 1 | 6.38 |
| CHEMBL2152253 | — | — | 1 | 6.38 |
| CHEMBL2152144 | — | — | 1 | 6.36 |
| CHEMBL2152127 | — | — | 1 | 6.34 |
| CHEMBL2152136 | — | — | 1 | 6.27 |
| CHEMBL2152146 | — | — | 1 | 6.27 |
| CHEMBL2152142 | — | — | 1 | 6.26 |
| CHEMBL2152140 | — | — | 1 | 6.25 |
| CHEMBL2152132 | — | — | 1 | 6.20 |
| CHEMBL2152252 | — | — | 1 | 6.16 |
| CHEMBL2152250 | — | — | 1 | 6.13 |
| CHEMBL2152126 | — | — | 1 | 6.09 |
| CHEMBL2152145 | — | — | 1 | 5.99 |
| CHEMBL2152150 | — | — | 1 | 5.99 |
| CHEMBL2152131 | — | — | 1 | 5.97 |
| CHEMBL2152129 | — | — | 1 | 5.96 |
| CHEMBL2152124 | — | — | 1 | 5.95 |
| CHEMBL2152149 | — | — | 1 | 5.93 |
| CHEMBL2152134 | — | — | 1 | 5.92 |
| CHEMBL2152147 | — | — | 1 | 5.90 |
| CHEMBL2152255 | — | — | 1 | 5.88 |
| CHEMBL2152143 | — | — | 1 | 5.87 |
| CHEMBL2152133 | — | — | 1 | 5.85 |
| CHEMBL2152135 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152257 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2152139 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2152256 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL2152148 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2152130 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL2151050 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL2152141 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL2152253 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL2152144 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL2152127 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL2152136 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL2152146 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL2152142 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL2152140 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL2152132 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL2152252 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2152250 | — | IC50 | = | 743.0 | nM | 6.13 |
| CHEMBL2152126 | — | IC50 | = | 816.0 | nM | 6.09 |
| CHEMBL2152145 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL2152150 | — | IC50 | = | 1032.0 | nM | 5.99 |
| CHEMBL2152131 | — | IC50 | = | 1073.0 | nM | 5.97 |
| CHEMBL2152129 | — | IC50 | = | 1095.0 | nM | 5.96 |
| CHEMBL2152124 | — | IC50 | = | 1134.0 | nM | 5.95 |
| CHEMBL2152149 | — | IC50 | = | 1186.0 | nM | 5.93 |
| CHEMBL2152134 | — | IC50 | = | 1202.0 | nM | 5.92 |
| CHEMBL2152147 | — | IC50 | = | 1253.0 | nM | 5.90 |
| CHEMBL2152255 | — | IC50 | = | 1316.0 | nM | 5.88 |
| CHEMBL2152143 | — | IC50 | = | 1355.0 | nM | 5.87 |
| CHEMBL2152133 | — | IC50 | = | 1418.0 | nM | 5.85 |
| CHEMBL2152135 | — | IC50 | = | 1582.0 | nM | 5.80 |
| CHEMBL2152251 | — | IC50 | = | 2452.0 | nM | 5.61 |
| CHEMBL2152138 | — | IC50 | = | 2964.0 | nM | 5.53 |
| CHEMBL2152137 | — | IC50 | = | 3389.0 | nM | 5.47 |
| CHEMBL2152125 | — | IC50 | = | 4204.0 | nM | 5.38 |
| CHEMBL2152254 | — | IC50 | = | 4389.0 | nM | 5.36 |
| CHEMBL2152128 | — | IC50 | = | 8359.0 | nM | 5.08 |