Assay Detail
Binding
CHEMBL2157771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum recombinant HGPRT expressed in Escherichia coli using Prib-PP as substrate by spectrophotometric assay in presence of guanine
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.20 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153484 | — | — | 1 | 7.00 |
| CHEMBL2153477 | — | — | 1 | 7.00 |
| CHEMBL2153487 | — | — | 1 | 7.00 |
| CHEMBL2153490 | — | — | 1 | 6.70 |
| CHEMBL2153483 | — | — | 1 | 6.70 |
| CHEMBL2153497 | — | — | 1 | 6.70 |
| CHEMBL2153480 | — | — | 1 | 6.70 |
| CHEMBL2153485 | — | — | 1 | 6.52 |
| CHEMBL2153493 | — | — | 1 | 6.40 |
| CHEMBL2153496 | — | — | 1 | 6.40 |
| CHEMBL2153492 | — | — | 1 | 6.22 |
| CHEMBL2153482 | — | — | 1 | 6.16 |
| CHEMBL2153478 | — | — | 1 | 5.89 |
| CHEMBL2153476 | — | — | 1 | 5.77 |
| CHEMBL2153486 | — | — | 1 | 5.72 |
| CHEMBL2153495 | — | — | 1 | 5.58 |
| CHEMBL2153481 | — | — | 1 | 5.40 |
| CHEMBL2153491 | — | — | 1 | 5.22 |
| CHEMBL2153498 | — | — | 1 | 4.80 |
| CHEMBL2153489 | — | — | 1 | - |
| CHEMBL2153479 | — | — | 1 | - |
| CHEMBL2153488 | — | — | 1 | - |
| CHEMBL2153494 | — | — | 1 | - |
| CHEMBL2153499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153484 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2153477 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2153487 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2153490 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2153483 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2153497 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2153480 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2153485 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2153493 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2153496 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2153492 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL2153482 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL2153478 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2153476 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL2153486 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL2153495 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL2153481 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2153491 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL2153498 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL2153489 | — | Ki | >= | 250000.0 | nM | - |
| CHEMBL2153479 | — | Ki | - | — | - | |
| CHEMBL2153488 | — | Ki | >= | 220000.0 | nM | - |
| CHEMBL2153494 | — | Ki | >= | 210000.0 | nM | - |
| CHEMBL2153499 | — | Ki | >= | 200000.0 | nM | - |