Assay Detail
Binding
CHEMBL2157772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium vivax HGPRT using Prib-PP as substrate by spectrophotometric assay in presence of guanine
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium vivax |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.34 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153483 | — | — | 1 | 7.30 |
| CHEMBL2153480 | — | — | 1 | 6.52 |
| CHEMBL2153490 | — | — | 1 | 6.16 |
| CHEMBL2153485 | — | — | 1 | 6.05 |
| CHEMBL2153497 | — | — | 1 | 5.85 |
| CHEMBL2153476 | — | — | 1 | 5.82 |
| CHEMBL2153494 | — | — | 1 | 5.80 |
| CHEMBL2153477 | — | — | 1 | 5.40 |
| CHEMBL2153481 | — | — | 1 | 5.10 |
| CHEMBL2153486 | — | — | 1 | 4.96 |
| CHEMBL2153498 | — | — | 1 | 4.96 |
| CHEMBL2153496 | — | — | 1 | 4.89 |
| CHEMBL2153487 | — | — | 1 | 4.68 |
| CHEMBL2153495 | — | — | 1 | 4.68 |
| CHEMBL2153484 | — | — | 1 | 4.60 |
| CHEMBL2153482 | — | — | 1 | 4.55 |
| CHEMBL2153493 | — | — | 1 | 4.39 |
| CHEMBL2153489 | — | — | 1 | 4.33 |
| CHEMBL2153478 | — | — | 1 | - |
| CHEMBL2153479 | — | — | 1 | - |
| CHEMBL2153492 | — | — | 1 | - |
| CHEMBL2153491 | — | — | 1 | - |
| CHEMBL2153488 | — | — | 1 | - |
| CHEMBL2153499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153483 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL2153480 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2153490 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL2153485 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL2153497 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL2153476 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL2153494 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL2153477 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2153481 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL2153486 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL2153498 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL2153496 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL2153487 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2153495 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2153484 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL2153482 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL2153493 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL2153489 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL2153478 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL2153479 | — | Ki | - | — | - | |
| CHEMBL2153492 | — | Ki | = | 178000.0 | nM | - |
| CHEMBL2153491 | — | Ki | > | 230000.0 | nM | - |
| CHEMBL2153488 | — | Ki | > | 250000.0 | nM | - |
| CHEMBL2153499 | — | Ki | >= | 250000.0 | nM | - |