Assay Detail
Binding
CHEMBL2157804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-MLA from alpha7 nAChR in rat brain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.42 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151439 | FACINICLINE | 2.0 | 1 | 8.00 |
| CHEMBL2151440 | — | — | 1 | 7.21 |
| CHEMBL2151443 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151439 | FACINICLINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2151440 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL2151443 | — | Ki | = | 88.0 | nM | 7.06 |