Assay Detail
Binding
CHEMBL2157806
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5HT3 receptor
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.49 | 7.16 |
| Ki | 2 | 8.49 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151439 | FACINICLINE | 2.0 | 1 | 8.70 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.28 |
| CHEMBL603052 | — | — | 1 | 7.16 |
| CHEMBL378349 | — | — | 1 | 6.73 |
| CHEMBL597241 | — | — | 1 | 6.32 |
| CHEMBL378471 | — | — | 1 | 6.24 |
| CHEMBL379302 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151439 | FACINICLINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL56564 | TROPISETRON | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL603052 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL378349 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL597241 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL378471 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL379302 | — | IC50 | = | 962.0 | nM | 6.02 |