Assay Detail
Functional
CHEMBL2157808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha7 nAChR
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.75 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378471 | — | — | 1 | 7.37 |
| CHEMBL378349 | — | — | 1 | 7.32 |
| CHEMBL1258005 | — | — | 1 | 7.30 |
| CHEMBL379302 | — | — | 1 | 7.07 |
| CHEMBL212669 | — | — | 1 | 7.00 |
| CHEMBL1086089 | — | — | 1 | 6.92 |
| CHEMBL1084363 | — | — | 1 | 6.89 |
| CHEMBL597241 | — | — | 1 | 6.80 |
| CHEMBL603052 | — | — | 1 | 6.80 |
| CHEMBL2151569 | — | — | 1 | 6.50 |
| CHEMBL565963 | — | — | 1 | 6.46 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 5.89 |
| CHEMBL2151443 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378471 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL378349 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1258005 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL379302 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL212669 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1086089 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1084363 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL597241 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL603052 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2151569 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL565963 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL56564 | TROPISETRON | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2151443 | — | EC50 | = | 4260.0 | nM | 5.37 |