Assay Detail

CHEMBL2160259

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Functional

Cytotoxicity against telomerase positive human MCF7 cells after 96 hrs by SRB assay

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

Open DB target context

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.

Soares J, Keppler BR, Wang X, Lee KH, Jarstfer MB.
Bioorg Med Chem Lett (2011) 21 : 7474 -7478
PubMed 22044621 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.05	6.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL187266	TANSHINONE IIA	—	1	6.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL187266	TANSHINONE IIA	EC50	=	900.0	nM	6.05