Assay Detail
Binding
CHEMBL2160264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pre-assembled human recombinant telomerase activity in rabbit reticulocytes after 90 mins by gel electrophoresis method based direct primer extension assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | — | 1 | 6.30 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | = | 500.0 | nM | 6.30 |