Assay Detail
Functional
CHEMBL2160279
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Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.63 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2158588 | — | — | 1 | 9.66 |
| CHEMBL2158596 | — | — | 1 | 9.60 |
| CHEMBL2158589 | — | — | 1 | - |
| CHEMBL2158598 | — | — | 1 | - |
| CHEMBL2158597 | — | — | 1 | - |
| CHEMBL2158595 | — | — | 1 | - |
| CHEMBL2158594 | — | — | 1 | - |
| CHEMBL2158591 | — | — | 1 | - |
| CHEMBL2158590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2158588 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL2158596 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL2158589 | — | IC50 | - | — | - | |
| CHEMBL2158598 | — | IC50 | - | — | - | |
| CHEMBL2158597 | — | IC50 | - | — | - | |
| CHEMBL2158595 | — | IC50 | - | — | - | |
| CHEMBL2158594 | — | IC50 | - | — | - | |
| CHEMBL2158591 | — | IC50 | > | 3.0 | nM | - |
| CHEMBL2158590 | — | IC50 | > | 3.0 | nM | - |